Management of propofol-related infusion syndrome and discussion of <i>POLG</i> mitochondrial mutation: a case report

Background: Propofol-related infusion syndrome (PRIS) is a known complication of long-term propofol infusion. Providers should be aware PRIS risk, as early recognition key to avoiding mortality, which can range from 30% 60%. The underlying mechanism unknown, but some studies suggest that mitochondrial dysfunction may predispose patients developing PRIS. Case Report: We present case refractory adult-onset epilepsy was challenging due paradoxical response with worsening brief ictal/interictal rhythmic discharges and complicated by development aimed discuss the clinical presentations PRIS, along review POLG mutation found in our patient, has also been described other reports epilepsy. Conclusions: treatment strategy utilized hopes raising awareness risks managing who have potential disorder.